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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6d36ccfbbfc3b513790bf8751a90d3b32c589167061c8a387198dcd33349cd6a' 
  AND token = '1O63ff//72TmrBly30EAgCVuG2jbfAeNZHprL/r54MY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}