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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2c3219cad875c68de881bd553cbcb67b49f765248cc0cc5c49c7e428c0cfa9ac' 
  AND token = 'U3HWpjrS+nyIAq1v9f+ZXn2Bb69EtXLh+vrKdGMT0Qk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}