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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6b0c7f05bfab954c5879bdf30255ca7a259e0f08fc643d2e3f51775359321c16' 
  AND token = 'uO9orq22rLc8d/qyFCJ1ayzLutAd1ShhEESIJsKmItE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00054

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}