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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1a4f5d90e400d3cfa693ad228ee24d6f6b3b4844307c8950a7550b2a64dd14dd' 
  AND token = 'bJGbTRJ2eT8m73/kmXvkhKeRg4QRzDcSVeIYhtjihSA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}