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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '286f0e14ef48167c6ba036e892a88a0e6f05872a30fc8ed6a122ecc237a59b47' 
  AND token = 'JQeFKMBI+LzA8Pr2lXz1XibB3pDgILbGs7eR/OZBucQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}