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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b721e07e10e7406db23c3dbe3db4729b1bd6f9da09bd61821786b6c0047e7377' 
  AND token = 'EZXJIoyLiZLPvYrLyKvYVmuniH2Z7l0L30LnIdoScJo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}