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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8f60e54b6a969a4cca902c3984066e33884e53bcb33699433d852911a7db8725' 
  AND token = '2lZcAcZlpcARYuxt70GKYfu+BpGe60/JATNmVRrnUac=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}