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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fbdf8056c238897080632005b6384fa6c1acb9be43484ce3a8b9b72d63da4c18' 
  AND token = 'DmuTzp15X4QekxlE8OidwyMMF0OfE69gGpoSgdiWQ1Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}