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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0143d57f2e5d729cb47e44463fd2ad0da52993254a6b958f076334c48be6b94f' 
  AND token = 'e/lQMT8PuQbvCki/j3UOT4kwFdEOUliLfFe/F3vulg0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}