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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1ccfacbbcb56aab6257dadf4ad2ae1532fdf0099cfa99f6d955223726530ec8c' 
  AND token = 'gpe+ESNzcmfCu1MGOB0Ooxz18Ner8zmJkzhfqlq5fHE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}