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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21c43e48038bb65bf21c07ede30e4a67743e6c01aa5cf39823b27007e5fd6f46' 
  AND token = 'xdwYS4wgKTgH1PDvn2TdSKut6X/ce9EnNPtlzVi2SlQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}