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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9a78d93164504d4afa243660c4aab41768a4f0a4a008078c5ae6a3374436f111' 
  AND token = 'agRHJDaVmILcUGmGwvFHbtty+jKxhbCmN5BR2ZshmMU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}