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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78dbb7d3d7dfe1f49ceb6279477233a8cb3fe2b6bcd24c75503583f2382d12a3' 
  AND token = 'uBCURU4MY1VaCqg4GKGMMrXlMtGf0Zoa0IWylPi9YVw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}