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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e2f69f44a472b87579cc35fa0c40514c88506b046601b6224097bfed072499c3' 
  AND token = 'kIFtTLZsEW4PnGpIOd8oCQX+v4ciryz7s6fYgvhoAMI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}