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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e289dff2a61e71079154692b73910db597a29aa3c0740120593d395fd342ea85' 
  AND token = 'Ga5E9QCY9gtdv2YxibCk/nDXgAQtteMT/mjzn9XhOR0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00077

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}