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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80a6ecaf816f208584ccf65a20dd6c4dfc1bbbe583644c9bb49f328bb2195f05' 
  AND token = 'jKH8QehamvFTOmhbKO0V5e4pkp0dpq6NZtDGlA9Lobs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00051

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}