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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cd8c294df3575610dfb0d6d1435509c3df4c12591acc803cdae45ac2d006f721' 
  AND token = 'v/QHYQB83zL9Ro+SwQ1JWiB3c6pftXuYuhm/bTrl5mY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}