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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e33a05a2b734f34c3c77ec7d635c37dee909241598d66275c7122395c0c2f34c' 
  AND token = 'PW/UI1A4h5B/cbDbRQ1jSIqZVy3svmyQcy2blB77UR8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}